Psycho
The psychos of the supervillain, Doctor Demented, are innocent women that he abducted and twisted to his will effectively turning them into henchmen to do his bidding. They are part of the collective term for his minions known as The Demented. He uses different methods or combinations to achieve his results. The doctor will use technology in some cases, for example his hypno-goggles, to weaken the resolve of the victim. In the case of more submissive minds, this can be enough to allow him to hypnotically suggest whatever he wants, thereby changing the thoughts of the victim. He developed tech that can be bolted directly into the skull and overthrows the neurons in the brain, changing the actual brain chemistry and this also achieves his dark goals. In the most willful and stubborn cases, or in the case of metahumans, the doctor will perform a lobotomy. In such a state, the patient no longer resists the doctor at all, but this often results in the Demented Psycho minions. The effect of their brainwashing and brain damage is absolutely irreversible.